Asymmetric Cortical Atrophy in the Primary Progressive Aphasias

We present two patients with variants of primary progressive aphasia (PPA), with differing patterns of atrophy on MRI. Clinical deficits in this condition depend on the location of focal atrophy. We present imaging findings in two patients with different variants of PPA, which serve to highlight the differentiation of this condition into distinct aphasic syndromes, as well as the utility of structural imaging in its diagnosis.

Keywords: Primary progressive aphasia;semantic dementia; progressive non-fluent aphasia; magnetic resonance imaging; asymmetric cortical atrophy.